Document Type : Original Article


1 Department of Epidemiology, Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Epidemiology, Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran/Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran


Background and aims: Brucellosis is one of the most common infectious diseases in both humans and animals. It has been controlled in developed countries; however, it is still regarded as a public health problem in developing countries including Iran. The aim of this study was to investigate the epidemiology of human brucellosis in Isfahan province.
Methods: The present study is a cross-sectional descriptive study investigating the epidemiology of human brucellosis in Isfahan province from 2010 to 2015. Sampling was done using Isfahan’s disease registry database. Chi-square and t test were used for analyzing the data, and all data analyses were performed using SPSS software version 21.0.
Results: A total of 3,245 patients were included in this study, and their mean (SD) age was 35.29 (18.00) years. The age group of 15-25 years with a frequency of 23.80% had the highest frequency of the disease. The annual incidence of the disease from 2010 to 2014 shows an increasing trend, reaching from 6.25 to 15 per 100 000 people. It was reduced in 2015 and reached 12.25 per 100 000. In addition, the highest incidence was observed in July.
Conclusion: This study implies that the trend of human brucellosis has been increasing over the years, so it is recommended that people be educated on how to prevent it in humans and animals. The results of this study can help health administrators in the province to more effectively control the disease at the provincial level by identifying high-risk cities and focusing on health care in these areas.


1. Corbel MJ. Brucellosis in Humans and Animals. Geneva: World Health Organization; 2006. 
2. Skalsky K, Yahav D, Bishara J, Pitlik S, Leibovici L, Paul M. Treatment of human brucellosis: systematic review and meta-analysis of randomised controlled trials. BMJ. 2008;336(7646):701-4. doi: 10.1136/bmj.39497.500903.25. 
3. S. Shahriari MAg, Haghdoost AA, Z worshiping, R. Khawaja Kazemi, Zafar Prysayy. Demographic and epidemiological investigation of brucellosis in Kohgiluyeh and Boyer- Ahmad in the years 1388 to 1392. Armaghan-e- Danesh. 1394. Availabe from: ViewPaper.aspx?ID=482252 
4. Memish ZA, Balkhy HH. Brucellosis and international travel. J Travel Med. 2004;11(1):49-55. doi: 10.2310/7060.2004.13551. 
5. Sofian M, Aghakhani A, Velayati AA, Banifazl M, Eslamifar A, Ramezani A. Risk factors for human brucellosis in Iran: a case-control study. Int J Infect Dis. 2008;12(2):157-61. doi: 10.1016/j.ijid.2007.04.019. 
6. Hajari A, Shams M, Afrooghi S, Fadaei Nobari R, Abaspoor Najafabadi R. Using the precede-proceed model in needs assessment for the prevention of brucellosis in rural areas of Isfahan, Iran. Armaghane Danesh. 2016;21(4):396-409. [Persian]. 
7. Assenga JA, Matemba LE, Muller SK, Malakalinga JJ, Kazwala RR. Epidemiology of Brucella infection in the human, livestock and wildlife interface in the Katavi- Rukwa ecosystem, Tanzania. BMC Vet Res. 2015;11:189. doi: 10.1186/s12917-015-0504-8. 
8. Gwida M, Al Dahouk S, Melzer F, Rösler U, Neubauer H, Tomaso H. Brucellosis - regionally emerging zoonotic disease? Croat Med J. 2010;51(4):289-95. doi: 10.3325/ cmj.2010.51.289. 
9. Tabatabayi A. Diseases of Animals Due to Bacteria. Tehran: University of Tehran Press; 2005. [Persian]. 
10. Ebrahimpour S. A note on brucellosis vaccine. Crescent J Med Biol Sci. 2015;2(1):32-3. 
11. Kassiri H, Amani H, Lotfi M. Epidemiological, laboratory, diagnostic and public health aspects of human brucellosis in western Iran. Asian Pac J Trop Biomed. 2013;3(8):589- 94. doi: 10.1016/s2221-1691(13)60121-5. 
12. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. Harrison’s Principles of Internal Medicine (Volume 2). USA: McGraw-Hill; 2005. 
13. Pakzad I, Bahmani S, Ghafouryan S, Hosainzadegan H. Diagnosis of human brucellosis by PCR using l7/l12 and 16srRNA genes compared with common serological tests. Arak Medical University Journal. 2012;14(6 Suppl 3):31-9. [Persian]. 
14. Farazi AA, Hosseini SD. Diagnostic validity of the conventional brucellosis serological tests in. Arak Medical University Journal. 2012;14(6 Suppl 3):71-7. [Persian]. 
15. Majidzadeh K, Hosseini SZ, Soleimani M, Ghalyanchi A. Rapid detection of causative agents of Malta fever using polymerase chain reaction. Ann Mil Health Sci Res. 2010;8(2):85-91. [Persian]. 
16. Shirzadi MR, Rezaei F. Guideline for the diagnosis and management of brucellosis. Tehran: Andishmand; 2013. [Persian]. 
17. Yavari EB. Epidemiology of Common Disorders in Iran. Tehran: Gap Nashr; 2014. [Persian]. 
18. Zemestani A, Faghiri-Beirami N, Hosseinzadeh- Fasaghandis A, Hashemi-Aghdam SR, Ebrahimzadeh A. Descriptive epidemiology of human brucellosis in Oskou county. Depiction of Health. 2016;7(1):34-42. [Persian]. 
19. Mohammedan MAH. Evaluate the epidemiology of the disease brucellosis Tyran and over a period of 14 Salhdr city, Isfahan. Journal of Medical School Isfahan. 2014; 32(293): 1103-9. [Persian]. 
20. Sahargahi B, Rezaei M, Naderi M, Ajdar F, Qubadi M. Comparison of the human brucellosis incidence trend in Eslam Abad-e-Gharb town, Kermanshah province and Iran (2006-2010). Journal of Kermanshah University of Medical Sciences. 2014;18(2):122-4. doi: 10.22110/jkums. v18i2.1048. [Persian]. 
21. Esmaeilnasab N, Banafshi O, Ghaderi E, Bidarpour F. Epidemiologic change investigation of brucellosis in Kurdistan province in 2006-2007. J Vet Med. 2007;1(3):53- 8. [Persian]. 
22. Soleimani A, Alizadeh S, Seif-Farshad M, Kusha M, Mohamdzadeh M, Haghiri L, et al. Descriptive epidemiology of human brucellosis in East Azerbaijan, 2001-2009. Medical Journal of Tabriz University of Medical Sciences. 2012;34(1):63-9. [Persian]. 
23. Kashfi M, Hatamian N, Rakhshani T. Epidemiological study of the brucellosis in Iran, Andimeshk, 2001-2016. Journal of Health Sciences & Surveillance System. 2018;6(1):23-8. 
24. Ali S, Nawaz Z, Akhtar A, Aslam R, Zahoor MA, Ashraf M. Epidemiological investigation of human brucellosis in Pakistan. Jundishapur J Microbiol. 2018;11(7):e61764. doi: 10.5812/jjm.61764. 
25. Majalija S, Luyombo P, Tumwine G. Sero-prevalence and associated risk factors of brucellosis among malaria negative febrile out-patients in Wakiso district, Central Uganda. BMC Res Notes. 2018;11(1):803. doi: 10.1186/s13104-018- 3907-3. 
26. Taheri Soodejani M, Lotfi MH, Ghaderi A, Reisi A, Mohammadzadeh M. Epidemiology of brucellosis in Shahr-e-Kord during the years 2010 to 2014. Pars Journal of Medical Sciences. 2016;14(1):1-7. doi: 10.29252/jmj.14.1.1. [Persian]. 
27. Ebrahimpour S, Youssefi MR, Karimi N, Kaighobadi M, Tabaripour R. The prevalence of human brucellosis in Mazandaran province, Iran. Afr J Microbiol Res. 2012;6(19):4090-4. doi: 10.5897/ajmr11.1076. 
28. Mosavi MH, Shavisi N, Mostafavi E. Epidemiological features survey of Malta fever in Gylangharb city, Kermanshah province. Journal of Zoonoses Research. 2013;1(2):31-7. [Persian]. 
29. Maleki F, RafieManesh H, Abbasi-Ghahramanloo A, Ghadimi N, Kousha A, Safiri S. Epidemiological characteristics of human brucellosis in Shahin Dezh, Western Azarbaijan, Iran, 2008-2012. Arch Clin Infect Dis. 2015;10(1):e22279. doi: 10.5812/archcid.22279.