Zika virus is an Arbovirus identified first time in 1947 in Uganda among Rhesus monkeys during study on yellow fever.1 Then, human cases were detected in 1952 in Uganda and Tanzania.2 Zika virus outbreaks have been reported in Africa, America, Asia and the Pacific.3 In fact, from 1960 to 1980, human infection with this virus has been reported in Africa and Asia.4 First main outbreak of Zika was reported from the Island of Yap in Micronesia in 2007.5 In July 2015, the relationship between the Zika virus and Guillain-Barre syndrome was reported in Brazil.6 In October 2015, the relationship between Zika virus infection and microcephaly was also reported from Brazil.7 From January 2014 to February 2016, Zika virus was endemic in 33 countries.8 Zika virus is transmitted by bite of mosquitoes from Aedes genus, especially Aedes aegypti in tropical areas.3 Transmission of Zika virus may also occur by mosquitoes of the genus Culex.9 Sexual transmission is likely as well.10,11 The World Health Organization declared that the Zika virus is a highly serious issue.3 Zika epidemic is a threat far greater than the Ebola outbreak, because Zika epidemic is characterized by the microcephaly in newborns as well as rapid spread around the world, the most dangerous threat to global health.12-15 In fact, Zika virus has caused serious concern in the world since October 2015, is expanding rapidly in Latin America, and has caused the birth of more than 4,000 children with small head and brain.12 Only 20% of infected people present signs of active Zika virus in the body.16 People with this disease have fever and pain; in fact, symptoms are flu-like.2,8 Pregnancy is the most dangerous period for Zika virus infection, because the virus can lead to neurological disorders in the growth of the baby in the uterus and may destroy growing brain cells and microcephaly.9,17 The World Health Organization has urged Asian countries to be vigilant about the risk of spreading Zika virus and preventive measures to control it.18 At present, China, Philippines, Thailand, and Indonesia are the most vulnerable countries to the spread of Zika epidemic. If it is not controlled quickly in this area more than two billion and 600 million of the world's population will be at serious risk.19 Iran, as an Asian country, has the mosquitoes vectors and therefore can be exposed to the risk of transmission of Zika.20-23
In Iran, 64 species of mosquitoes from Culicidea family have been reported three of which belong to the Aedes genus, and one of which is Aedes albopictus.24 Iran also has suitable climate for endemic transmission of Zika virus.25 Immigrants from neighboring countries for economic reasons, could increase the risk of disease transmission in Iran.26
The virus can be transmitted through sexual intercourse, and therefore Iranians travelling to East Asia may increase the risk of disease transmission.14 The destination countries of Iranian passengers, especially in East Asia, are at risk or have been reported to have cases of Zika.17 So, traveling to areas where active Zika virus exists and its transmission is common, could potentially increase the risk of transmission of Zika. The possibility of virus transmitting is higher in the summer and during the vacations.17,27-29 Close supervision alongside the borders is necessary when foreign people enter the country. Application of appropriate methods of mosquito control and personal protection is important to fight against disease.