Molecular Genetics and Epidemiology of Vitiligo

Document Type: Review article

Authors

1 Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Social Health Determinants Research Center, Shahrekord University of Medical Sciences, Shahrekrod, I.R. Iran.

3 Skin Disease and Leishmaniasis Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background: Vitiligo is an acquired, idiopathic, and common depigmentation disorder of the skin that affects people of all ages and both sexes equally in the worldwide. Although etiology of the disease is unknown, there are theories such as environment and genetic factors.
Methods: In this article, we collected and summarized the appropriate manuscripts regarding the epidemiology and genetics by using the terms vitiligo and genetic epidemiology in PubMed and Google scholar.
Results: Studies showed the highest prevalence of disease in African countries, but with regard to distribute disease in different areas, environmental factors are as other causes of vitiligo and three genes FOXP3, XBP1 and TSLP had the most association with the disease.
Conclusion: It seems that recognition of the genetic base of vitiligo will supply new insight therapies for its. Therefore, more genetic studies are needed to discover the genes and causes linked to clinical aspects of this disease.

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