Epidemiology and Estimating the Risk Factors for the Transfer of Hepatitis B Virus Using Multivariate Analysis Model: A Retrospective Case-Control Study

Document Type: Original Article


1 Colorectal Research Center, Iran University of Medical Science, Tehran, Iran

2 Internal Medicine Department, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran


Background and aims: Hepatitis B virus (HBV) is one of the important public health diseases in Iran.
Therefore, to control the prevalence of the disease, knowledge is required regarding the risk factor of
HBV. Accordingly, the aim of this study was to determine the risk factors of HB transmission.
Methods: A retrospective case-control study was conducted on the possible risk factors of HBV
transmission. To this end, a total of 171 patients with HBV infection and 171 controls from Rasoul-e-
Akram hospital were investigated during 2015-2018. All subjects were directly evaluated using a faceto-
face questionnaire about demographic aspects. Finally, HBV infection and its risk factors among the
subjects were detected using hepatitis B surface antigen test.
Results: Overall, 171 HBV patients including 77 (42%) males and 93 (58%) females were evaluated.
The mean age of the participants was 40 ± 13 years. Univariate logistic analysis showed that HBV
infection in these cases was associated with addiction injection (odds ratio [OR] = 4.08, CI:1.3-
9.57), family history (OR = 4.52, CI: 1.27-10.7), and having a history of blood transfusion (OR =
3.16, CI: 1.52-5.37). There were no significant relationships between the liver function tests, alcohol
consumption, the history of dental visits, and HBV participants. In addition, the logistic-regression
model proved that patients with a history of HBV-infected parents (At least one of them) and addiction
injection were severely subject to HB infection. In other words, there was a significant association
between a history of HBV-infected parents and addiction injection and HB infection.
Conclusion: In general, HBV infection was strongly related to having a family member infected with
hepatitis B, suffering from addiction injection, and having blood injection.


Main Subjects

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