Document Type: Review article
Assistant Professor of Reproductive Health, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
PhD in Health Promotion, Research Center for Health Sciences, Education Development Center, Hamadan University of Medical Sciences, Hamadan, Iran
MSc in Community Nutrition, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Background and aims: Fennel is often advocated for primary dysmenorrhea. Whether this herb has a
real effect on pain relief is still a matter of debate in medicine. Therefore, this study was conducted to
evaluate the effect of fennel on primary dysmenorrhea.
Methods: This systematic review was conducted on clinical trials (non-randomized, randomized,
historical study with concurrent control) published in PubMed (MEDLINE), Web of Science, Scopus,
Cochrane Central Register of Controlled Trials (CENTRAL), ProQuest, and Persian databases (Magiran,
IranMedex, SID, Irandoc) regarding the effect of fennel on pain intensity in primary dysmenorrhea from
1990 to 2019. Nine studies met all inclusion criteria. Any clinical trials on young women with primary
dysmenorrhea were included in the study. Studies that used fennel plus other products investigated
fennel effect on premenstrual syndrome (PMS) and bleeding; studies without a control group and
nonclinical trials were excluded. In all studies, participants were young female university or high
school students. All of them had moderate to severe primary dysmenorrhea.
Results: In all of the studies except for one, fennel had been more effective than placebo in pain relief
(P < 0.01). Non-steroidal drugs had the same result as fennel for pain relief. However, in one study,
the difference between non-steroidal anti-inflammatory drugs (NSAIDs) and fennel in pain relief was
observed. Only one study reported increasing vaginal bleeding after fennel consumption in some
Conclusion: Collectively, these studies favored fennel over NSAID, other herbal drugs, and placebo.
But more investigation is needed to draw a firm conclusion.
Registration: PROSPERO - 42015023725