Document Type: Original Article

Authors

1 Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Cellular and Molecular Research Center, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran/Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Background and aims: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) which
involves the rectum and colonic mucosa, and is often constantly expanding. Few data are available on
risk factors in Chaharmahal and Bakhtiari province. Therefore, the aim of this study was to investigate
the association between potential risk factors and UC in Shahrekord.
Methods: A case-control study was conducted on patients diagnosed with UC. Overall, 27 new cases
of UC and 54 healthy controls in the age range of 20–80 years were studied. Participants were recruited
from Pathologic Centers in Shahrekord in 2018. Chi-square test and t test and were used. Logistic
regression model was employed to analyze the association between risk factors and UC disease.
Results: The mean age at diagnosis was 41.74 years (SD: 7.16 years) and 44.94 years (SD: 6.67
years) for case and control subjects, respectively. Moreover, univariate and multiple odds ratio (OR)
showed that there was no significant association between UC and any of the risk factors including
gender, marital status, education, diastolic blood pressure, history of diabetes, history of hypertension,
permanent use of piped water, night shift work, history of thyroid diseases, depression, history of fatty
liver disease, history of kidney stones, and sleep time and wake-up time in the morning.
Conclusion: Generally, no significant association was observed between UC and the variables in the
present study. Thus, further studies with larger sample size are necessary to better understand the other
risk factors and environmental determinants of UC.

Keywords