Background and aims: quality of life (QOL) is poor in hemodialysis (HD) patients. High oxidative stress and inflammatory conditions disturb their normal physiology, emotional, and physical functions. This study aimed to assess the effects of Pomegranate peel extract (PPE) alone and in combination with vitamin E (Vit E) as anti-oxidant and anti-inflammatory substances on QOL of HD patients using short-form 36 (SF-36) QOL questionnaire.
Methods: This study was a double blinded, placebo-controlled randomized clinical trial on HD patients. 100 HD Subjects were randomly divided in 4 equal groups: group Pom+VitE, which received 2 PPE tablets+1 VitE soft gel daily, group Pom, which received 2 PPE tablets+1 VitE placebo soft gel daily, group VitE, which received 1 VitE soft gel+2 PPE placebo tablets daily, and group Placebo, which received 2 PPE placebo tablets+1 VitE placebo soft gel daily. The intervention duration was 8 weeks. The method of stratified block randomization based on sex, age, HD duration, and employment status was used for randomization.
Results: The mean age of participants was ranged between 51–57 year with the HD duration of 9–11.2 months. Bodily pain score and general health score significantly increased in the Pom group and Pom+ Vit E group. The emotional role functioning score of Pom+Vit E group was significantly higher than the Placebo group (P