Document Type: Original Article


1 Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran

2 Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

3 Department of Epidemiology and Biostatistics, Health School, Kashan University of Medical Sciences, Kashan, Iran


Background: Von Willebrand disease (VWD) is an inherited disorder of blood clotting in humans. The prevalence of VWD is different among various populations. Rate of this disorder in women with menorrhagia is less reported in Asia and Iran. The present study was aimed to determine the prevalence of VWD in women of reproductive age with severe menstrual bleeding.
Methods: In this cross-sectional study, 160 women in the reproductive age group (15-45 years) with Heavy Menstrual Bleeding (HMB) referred to the Hematology Clinic of Kashan Shahid-Beheshti Hospital during 2018 were participated. The demographic and clinical data of each participate including age, menstrual intervals, having the uterine myoma and polyp were collected using a questionnaire, sonography and physical examination of women by a physician. The laboratory tests included the determination of hemoglobin (Hb), ferritin, Iron and total iron-binding capacity (TIBC).
Results: Fifteen patients (9.3%) with severe menstrual bleeding had VWD with the mean age of 34.60±6.85 years. Frequency of the uterine fibroid (Myoma) in women with VWD was significantly more than its rate in patients without VWD (p=0.03). The different of mean ferritin between women with and without VMD was about 7 ug/dL (P=0.001). The average of serum iron in total participants was 35.3±11.48 ug/dL and VMD patients had a lower iron than those without VMD (P=0.001).
Conclusion: VWD accounted for 9.3% of women of reproductive age with heavy menstrual bleeding in Kashan, Iran, which is lower than other regions of Asia.


Main Subjects