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Epidemiol Health System J. 2025;12(2): 94-101.
doi: 10.34172/ehsj.26368
  PDF Download: 1

Original Article

Dose-Response Relationship Between Social Support and Quality of Life in End-Stage Renal Disease

Fatemeh Farrokhian 1 ORCID logo, Toraj Ahmadi Jouybari 2 ORCID logo, Rasoul Gholamiveis 3 ORCID logo, Soudabeh Eskandari 1 ORCID logo, Tahereh Mohammadi Majd 3 ORCID logo, Naser Farahmand 4 ORCID logo, Mehdi Moradinazar 4* ORCID logo

1 Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of Epidemiology, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Social Development and Health Promotion Research Center, Health Policy and Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
*Corresponding Author: Mehdi Moradinazar, Email: m.moradinazar@gmail.com

Abstract

Background and aims: Evaluating quality of life is essential for addressing patients’ fundamental challenges and guiding treatment approaches. This study examined the quality of life and the factors influencing it among patients with chronic kidney disease (CKD).

Methods: This cross-sectional study was conducted in Western Iran over one year, using a census-based approach. Data were collected via the SF-36 Quality of Life Questionnaire and structured social support assessments. Crude and adjusted linear regression models were employed to assess associations.

Results: The results indicated that 92.4% of patients reported a moderate quality of life, while 32.8% experienced moderate social support. The mean quality of life score was 50.48±5.86, and the mean social support score was 42.29±5.65. Quality of Life scores increased steadily with rising social support, peaking around a score of 40, followed by a slight decline beyond this threshold. Adjusted regression analysis confirmed that social support significantly enhances quality of life (P=0.032; β=2.86, 95% CI: 1.77, 3.95). Additionally, individuals with higher economic status demonstrated better quality of life outcomes (P<0.001; β=2.48, 95% CI: 0.50, 4.46). Additional significant associations were observed for age group (P=0.01), smoking status (P=0.02), and support from welfare organizations (P=0.01).

Conclusion: This study established a direct association between quality of life and social support, with significant connections observed in physical health, social relationships, and overall well-being.


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Submitted: 19 Feb 2025
Revision: 23 Sep 2025
Accepted: 27 Sep 2025
ePublished: 02 Dec 2025
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